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1- Children Growth Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Children Growth Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences, Qazvin, Iran. , banafsheh.arad@gmail.com
Abstract:   (32 Views)
Introduction: Deficiency of 11-hydroxylase is clinically presented by external genitalia virilization in girls and precocious puberty in boys. Low renin hypertension occurs in both sexes. Early diagnosis and treatment of hypertension can prevent complications.
Case presentation: We described a 4.5 years old girl of 46.XX, who presented with ambiguous genitalia at birth and hypertension later in follow-up. The patient had received the appropriate dosage of hydrocortisone and the level of 17-hydroxy progesterone was within the acceptable range but the hypokalemia persisted. Both hypertension and hypokalemia were normalized when spironolactone was added.
Conclusion: Intermittent measurement of blood pressure is necessary for patients with 11β hydroxylase deficiency. In these patients, spironolactone is effective in treating mineralocorticoid-mediated hypertension and hypokalemia by blocking mineralocorticoid receptor.
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Type of Study: Case Report and Review of Literature | Subject: Endocrinology
Received: 2021/07/11 | Accepted: 2021/10/10

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