Volume 9, Issue 4 (In Press 2021)                   J. Pediatr. Rev 2021, 9(4): 3-3 | Back to browse issues page

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Asadollahi S, Neamatzadeh H, Namiranian N, Sobhan M R. Genetic of Legg-Calvé-Perthes Disease: A Review. J. Pediatr. Rev. 2021; 9 (4) :3-3
URL: http://jpr.mazums.ac.ir/article-1-395-en.html
1- Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , dr.msobhan@yahoo.com
Abstract:   (426 Views)
Legg-Calvé-Perthes (LCPD), a juvenile hip disorder, caused by blood flow impairment to the femoral head. In severe LCPD cases, the femoral head may develop a flattening deformity. Furthermore, if LCPD is diagnosed at the later stages, it causes early osteoarthritis of the hip. The etiology of LCPD is complex and embraces both genetic and epigenetic factors. This review is an attempt to summarize the current scholarship on the role of these genetic variants in the incidence of LCPD. Among the genetic causes of this disease are mutations in the genes of thrombophilia factors such as FV Leiden, and anticardiolipin antibodies. The mutation of COL2A1, TRPS1, eNOS genes are the other agents. Moreover, the clinical symptoms of avascular necrosis may be indiscernible in patients with Gaucher’s disease or LCPD and the differential diagnosis is a challenge.
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Type of Study: Narrative Review | Subject: Orthopedic surgery
Received: 2021/03/27 | Accepted: 2021/08/11 | Published: 2021/10/23

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