Journal of Pediatrics Review

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Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

Narges Karimi 1 , * and Athena Sharifi Razavi 2
Authors Information
1 Department of Neurology, Faculty of Medicine, Immunogenetics Research Center, Clinical Research Development Unit of Bou Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Neurology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Article information
  • Journal of Pediatrics Review: July 2017, 5 (2); e9813
  • Published Online: May 3, 2017
  • Article Type: Review Article
  • Received: December 5, 2016
  • Revised: April 9, 2017
  • Accepted: April 17, 2017
  • DOI: 10.5812/jpr.9813

To Cite: Karimi N, Sharifi Razavi A. Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review, J Pediatr Rev. 2017 ;5(2):e9813. doi: 10.5812/jpr.9813.

Copyright © 2017, Journal of Pediatrics Review. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Diagne CT, Diallo D, Faye O, Ba Y, Faye O, Gaye A, et al. Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infect Dis. 2015; 15: 492[DOI][PubMed]
  • 2. Zammarchi L, Tappe D, Fortuna C, Remoli ME, Gunther S, Venturi G, et al. Zika virus infection in a traveller returning to Europe from Brazil, March 2015. Euro Surveill. 2015; 20(23)[PubMed]
  • 3. Buathong R, Hermann L, Thaisomboonsuk B, Rutvisuttinunt W, Klungthong C, Chinnawirotpisan P, et al. Detection of Zika Virus Infection in Thailand, 2012-2014. Am J Trop Med Hyg. 2015; 93(2): 380-3[DOI][PubMed]
  • 4. Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, et al. Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro Surveill. 2014; 19(9)[PubMed]
  • 5. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol. 2016; 47(1): 6-7[DOI][PubMed]
  • 6. World Health Organization. .
  • 7. World Health Organization. . Consensus on causal link between Zika and neurologicaldisorders.
  • 8. World Health Organization. . Zika situation report.
  • 9. Chan JF, Choi GK, Yip CC, Cheng VC, Yuen KY. Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease. J Infect. 2016; 72(5): 507-24[DOI][PubMed]
  • 10. Besnard M, Lastere S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill. 2014; 19(13)[PubMed]
  • 11. Campos GS, Bandeira AC, Sardi SI. Zika Virus Outbreak, Bahia, Brazil. Emerg Infect Dis. 2015; 21(10): 1885-6[DOI][PubMed]
  • 12. Derraik JG, Slaney D. Notes on Zika virus--an emerging pathogen now present in the South Pacific. Aust N Z J Public Health. 2015; 39(1): 5-7[DOI][PubMed]
  • 13. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009; 360(24): 2536-43[DOI][PubMed]
  • 14. Cao-Lormeau VM, Roche C, Teissier A, Robin E, Berry AL, Mallet HP, et al. Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014; 20(6): 1085-6[DOI][PubMed]
  • 15. Dupont-Rouzeyrol M, O'Connor O, Calvez E, Daures M, John M, Grangeon JP, et al. Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis. 2015; 21(2): 381-2[DOI][PubMed]
  • 16. Hamel R, Liegeois F, Wichit S, Pompon J, Diop F, Talignani L, et al. Zika virus: epidemiology, clinical features and host-virus interactions. Microbes Infect. 2016; 18(7-8): 441-9[DOI][PubMed]
  • 17. World Health Organization. . WHO director-general briefs executive board on Zika situation.
  • 18. Chen LH, Hamer DH. Zika Virus: Rapid Spread in the Western Hemisphere. Ann Intern Med. 2016; 164(9): 613-5[DOI][PubMed]
  • 19. Dick GW, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952; 46(5): 509-20[PubMed]
  • 20. Diallo M, Thonnon J, Traore-Lamizana M, Fontenille D. Vectors of Chikungunya virus in Senegal: current data and transmission cycles. Am J Trop Med Hyg. 1999; 60(2): 281-6[PubMed]
  • 21. Musso D, Roche C, Nhan TX, Robin E, Teissier A, Cao-Lormeau VM. Detection of Zika virus in saliva. J Clin Virol. 2015; 68: 53-5[DOI][PubMed]
  • 22. Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011; 17(5): 880-2[DOI][PubMed]
  • 23. Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, et al. Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016; 65(3): 59-62[DOI][PubMed]
  • 24. Ministerio da Saude. . Microcefalia - Ministerio da Saudedivulgaboletimepidemiologico.
  • 25. Rudolph KE, Lessler J, Moloney RM, Kmush B, Cummings DA. Incubation periods of mosquito-borne viral infections: a systematic review. Am J Trop Med Hyg. 2014; 90(5): 882-91[DOI][PubMed]
  • 26. Fleming-Dutra KE, Nelson JM, Fischer M, Staples JE, Karwowski MP, Mead P, et al. Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection--United States, February 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(7): 182-7[DOI][PubMed]
  • 27. Alera MT, Hermann L, Tac-An IA, Klungthong C, Rutvisuttinunt W, Manasatienkij W, et al. Zika virus infection, Philippines, 2012. Emerg Infect Dis. 2015; 21(4): 722-4[DOI][PubMed]
  • 28. Olson JG, Ksiazek TG. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981; 75(3): 389-93[PubMed]
  • 29. Arzuza-Ortega L, Polo A, Pérez-Tatis G, López-García H, Parra E, Pardo-Herrera LC, et al. Fatal sickle cell disease and zika virus infection in girl from colombia. Emerg Infect Diseases. 2016; 22(5): 925-7[DOI]
  • 30. Centers for disease control and prevention. . Question and Answers: Zika virus infection (Zika) and pregnancy.
  • 31. Karwowski MP, Nelson JM, Staples JE, Fischer M, Fleming-Dutra KE, Villanueva J, et al. Zika Virus Disease: A CDC Update for Pediatric Health Care Providers. Pediatrics. 2016; 137(5)[DOI][PubMed]
  • 32. Schaffner F, Mathis A. Dengue and dengue vectors in the WHO European region: past, present, and scenarios for the future. Lancet Infect Dis. 2014; 14(12): 1271-80[DOI][PubMed]
  • 33. Kutsuna S, Kato Y, Takasaki T, Moi M, Kotaki A, Uemura H, et al. Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014 [corrected]. Euro Surveill. 2014; 19(4)[PubMed]
  • 34. Tappe D, Rissland J, Gabriel M, Emmerich P, Gunther S, Held G, et al. First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013. Euro Surveill. 2014; 19(4)[PubMed]
  • 35. Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Gunther S, et al. Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications. J Clin Virol. 2015; 63: 32-5[DOI][PubMed]
  • 36. Gourinat AC, O'Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M. Detection of Zika virus in urine. Emerg Infect Dis. 2015; 21(1): 84-6[DOI][PubMed]
  • 37. Heang V, Yasuda CY, Sovann L, Haddow AD, Travassos da Rosa AP, Tesh RB, et al. Zika virus infection, Cambodia, 2010. Emerg Infect Dis. 2012; 18(2): 349-51[DOI][PubMed]
  • 38. Simpson DI. Zika Virus Infection in Man. Trans R Soc Trop Med Hyg. 1964; 58: 335-8[PubMed]
  • 39. European centre for disease prevention and control (ECDC). . Rapid risk assessment: Zika virus infection outbreak, FrenchPolynesia.
  • 40. World Health Organization. . Epidemiological Alert: Neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas.
  • 41. ProMED-mail. . Zika virus-Brazil (16) (Pernambuco) microcephaly cause undetermined.
  • 42. Pan American Health Organization. . Epidemiological update.Neurological syndrome, congenital anomalies, and Zika virus infection.
  • 43. Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, et al. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell. 2016; 165(5): 1081-91[DOI][PubMed]
  • 44. Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, et al. Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission. Cell Host Microbe. 2016; 20(2): 155-66[DOI][PubMed]
  • 45. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016; 18(5): 587-90[DOI][PubMed]
  • 46. European centre for disease prevention and control. . Microcephaly in Brazil potentially linked to the Zika virus epidemic [Internet].
  • 47. Ventura CV, Maia M, Bravo-Filho V, Gois AL, Belfort R. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet Infect Dis. 2016; 387(10015): 228
  • 48. Vouga M, Baud D. Imaging of congenital Zika virus infection: the route to identification of prognostic factors. Prenat Diagn. 2016; 36(9): 799-811[DOI][PubMed]
  • 49. Sarno M, Sacramento GA, Khouri R, do Rosario MS, Costa F, Archanjo G, et al. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016; 10(2): 4517[DOI][PubMed]
  • 50. Johansson MA, Mier-y-Teran-Romero L, Reefhuis J, Gilboa SM, Hills SL. Zika and the Risk of Microcephaly. N Engl J Med. 2016; 375(1): 1-4[DOI][PubMed]
  • 51. World Health Organization. . Pregnancy management in the context of Zika virus: Interim guidance.
  • 52. Martines RB, Bhatnagar J, Keating MK, Silva-Flannery L, Muehlenbachs A, Gary J. Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses.
  • 53. Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016; 352(6287): 816-8[DOI][PubMed]
  • 54. Hazin AN, Poretti A, Di Cavalcanti Souza Cruz D, Tenorio M, van der Linden A, Pena LJ, et al. Computed Tomographic Findings in Microcephaly Associated with Zika Virus. N Engl J Med. 2016; 374(22): 2193-5[DOI][PubMed]
  • 55. Besnard M, Eyrolle-Guignot D, Guillemette-Artur P, Lastere S, Bost-Bezeaud F, Marcelis L, et al. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia. Euro Surveill. 2016; 21(13)[DOI][PubMed]
  • 56. Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, et al. Clinical and Imaging Findings in an Infant With Zika Embryopathy. Clin Infect Dis. 2016; 63(6): 805-11[DOI][PubMed]
  • 57. Petersen EE, Staples JE, Meaney-Delman D, Fischer M, Ellington SR, Callaghan WM, et al. Interim Guidelines for Pregnant Women During a Zika Virus Outbreak--United States, 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(2): 30-3[DOI][PubMed]
  • 58. de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, et al. Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016; [DOI][PubMed]
  • 59. Ventura CV, Maia M, Ventura BV, Linden VV, Araujo EB, Ramos RC, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016; 79(1): 1-3[DOI][PubMed]
  • 60. Miranda H2, Costa MC, Frazao MA, Simao N, Franchischini S, Moshfeghi DM. Expanded Spectrum of Congenital Ocular Findings in Microcephaly with Presumed Zika Infection. Ophthalmology. 2016; 123(8): 1788-94[DOI][PubMed]
  • 61. Miranda-Filho Dde B, Martelli CM, Ximenes RA, Araujo TV, Rocha MA, Ramos RC, et al. Initial Description of the Presumed Congenital Zika Syndrome. Am J Public Health. 2016; 106(4): 598-600[DOI][PubMed]
  • 62. Franca GV, Schuler-Faccini L, Oliveira WK, Henriques CM, Carmo EH, Pedi VD, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet. 2016; 388(10047): 891-7[DOI][PubMed]
  • 63. Sejvar JJ, Baughman AL, Wise M, Morgan OW. Population incidence of Guillain-Barre syndrome: a systematic review and meta-analysis. Neuroepidemiology. 2011; 36(2): 123-33[DOI][PubMed]
  • 64. European centre for disease prevention and control. . Rapid risk assessment: Zika virus epidemic in the Americas: potential association with microcephaly and Guillain-Barre syndrome. 2015;
  • 65. European Centre for Disease Prevention and Control. . Rapid risk assessment: Zika virus infection outbreak, French Polynesia. 2014;
  • 66. Minstério. S. . Protocolo de vigilancia e resposta a ocorrencia de microcefaliarelacionada a infecaopelo virus Zika. 2015;
  • 67. Fatima Vasco Aragao M, Linden V, Brainer-Lima AM. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ. 2016; : 353
  • 68. Oduyebo T, Petersen EE, Rasmussen SA, Mead PS, Meaney-Delman D, Renquist CM, et al. Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(5): 122-7[DOI][PubMed]
  • 69. Staples JE, Dziuban EJ, Fischer M, Cragan JD, Rasmussen SA, Cannon MJ, et al. Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(3): 63-7[DOI][PubMed]
  • 70. Kline MW, Schutze GE. What Pediatricians and Other Clinicians Should Know About Zika Virus. JAMA Pediatr. 2016; 170(4): 309-10[DOI][PubMed]
  • 71. Russell K, Oliver SE, Lewis L, Barfield WD, Cragan J, Meaney-Delman D, et al. Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(33): 870-8[DOI][PubMed]
  • 72. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016; 374(10): 951-8[DOI][PubMed]
  • 73. Masuzaki H, Miura K, Miura S, Yoshiura K, Mapendano CK, Nakayama D. Labor increases maternal DNA contamination in cord blood. ClinChem. 2004; 50: 1709-11
  • 74. Centers for Disease Control and Prevention. . CDC Newsroom: CDC adds countries to interim travel guidance related to Zika virus.
  • 75. European centre for disease prevention and control. . Rapid risk assessment: Zika virus disease epidemic: Potential association with microcephaly and guillain-barre syndrome. 2016;
  • 76. World Health Organization. . WHO statement on the 2nd meeting of IHR Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformation. 2016;
  • 77. Centers for disease control and prevention. . Cdc issues advice for travel to the 2016 summer olympic games.
  • 78. Cetron M. Revision to CDC's Zika Travel Notices: Minimal Likelihood for Mosquito-Borne Zika Virus Transmission at Elevations Above 2000 Meters.
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