Journal of Pediatrics Review

Published by: Kowsar

Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis

Raheleh Mirsadraee 1 , Mohamad Khajedaluee 2 , Rahim Vakili 2 , 3 , * , Azam Hasanabade 2 and Zahra Saeedrezaee 2
Authors Information
1 Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran
3 Medical Genetic Research Center, Department of Human Genetics, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Journal of Pediatrics Review: January 2017, 5 (1); e7462
  • Published Online: September 5, 2016
  • Article Type: Research Article
  • Received: June 7, 2016
  • Revised: August 6, 2016
  • Accepted: August 23, 2016
  • DOI: 10.17795/jpr-7462

To Cite: Mirsadraee R, Khajedaluee M, Vakili R, Hasanabade A, Saeedrezaee Z. et al. Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis, J Pediatr Rev. 2017 ;5(1):e7462. doi: 10.17795/jpr-7462.

Copyright © 2016, Mazandaran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Samardzic M, Terzic N, Popovic M. [Diabetic ketoacidosis in children with newly detected type 1 diabetes in Montenegro from 1999 to 2008]. Med Pregl. 2012; 65(11-12): 503-6[PubMed]
  • 2. Komulainen J, Lounamaa R, Knip M, Kaprio EA, Akerblom HK. Ketoacidosis at the diagnosis of type 1 (insulin dependent) diabetes mellitus is related to poor residual beta cell function. Childhood Diabetes in Finland Study Group. Arch Dis Child. 1996; 75(5): 410-5[PubMed]
  • 3. Diamond Project Group . Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999. Diabet Med. 2006; 23(8): 857-66[DOI][PubMed]
  • 4. Variation and trends in incidence of childhood diabetes in Europe. Lancet. 2000; 355(9207): 873-6
  • 5. Pishdad GR. Low incidence of type 1 diabetes in Iran. Diabetes Care. 2005; 28(4): 927-8[PubMed]
  • 6. Usher-Smith JA, Thompson MJ, Sharp SJ, Walter FM. Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults: a systematic review. BMJ. 2011; 343: 4092[DOI][PubMed]
  • 7. Bowden SA, Duck MM, Hoffman RP. Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. Pediatr Diabetes. 2008; 9(3 Pt 1): 197-201[DOI][PubMed]
  • 8. Abdul-Rasoul M, Habib H, Al-Khouly M. 'The honeymoon phase' in children with type 1 diabetes mellitus: frequency, duration, and influential factors. Pediatr Diabetes. 2006; 7(2): 101-7[DOI][PubMed]
  • 9. Hekkala A, Knip M, Veijola R. Ketoacidosis at diagnosis of type 1 diabetes in children in northern Finland: temporal changes over 20 years. Diabetes Care. 2007; 30(4): 861-6[DOI][PubMed]
  • 10. Komulainen J, Kulmala P, Savola K, Lounamaa R, Ilonen J, Reijonen H, et al. Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes Care. 1999; 22(12): 1950-5[PubMed]
  • 11. Schober E, Rami B, Waldhoer T, Austrian Diabetes Incidence Study G. Diabetic ketoacidosis at diagnosis in Austrian children in 1989-2008: a population-based analysis. Diabetologia. 2010; 53(6): 1057-61[DOI][PubMed]
  • 12. Rewers A, Klingensmith G, Davis C, Petitti DB, Pihoker C, Rodriguez B, et al. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study. Pediatrics. 2008; 121(5): 1258-66[DOI][PubMed]
  • 13. Dixon-Woods M, Sutton A, Shaw R, Miller T, Smith J, Young B, et al. Appraising qualitative research for inclusion in systematic reviews: a quantitative and qualitative comparison of three methods. J Health Serv Res Policy. 2007; 12(1): 42-7[DOI][PubMed]
  • 14. Limenis E, Shulman R, Daneman D. Is the frequency of ketoacidosis at onset of type 1 diabetes a child health indicator that is related to income inequality? Diabetes Care. 2012; 35(2): 5[DOI][PubMed]
  • 15. Veijola R, Reijonen H, Vahasalo P, Sabbah E, Kulmala P, Ilonen J, et al. HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group. J Clin Invest. 1996; 98(11): 2489-95[DOI][PubMed]
  • 16. Abdul-Rasoul M, Al-Mahdi M, Al-Qattan H, Al-Tarkait N, Alkhouly M, Al-Safi R, et al. Ketoacidosis at presentation of type 1 diabetes in children in Kuwait: frequency and clinical characteristics. Pediatr Diabetes. 2010; 11(5): 351-6[DOI][PubMed]
  • 17. Rosenbauer J, Icks A, Giani G. Clinical characteristics and predictors of severe ketoacidosis at onset of type 1 diabetes mellitus in children in a North Rhine-Westphalian region, Germany. J Pediatr Endocrinol Metab. 2002; 15(8): 1137-45[PubMed]
  • 18. Levy-Marchal C, Patterson CC, Green A, Eurodiab Ace Study Group. Europe . Geographical variation of presentation at diagnosis of type I diabetes in children: the EURODIAB study. European and Dibetes. Diabetologia. 2001; 44 Suppl 3: 75-80[PubMed]
  • 19. Hekkala A, Reunanen A, Koski M, Knip M, Veijola R, Finnish Pediatric Diabetes R. Age-related differences in the frequency of ketoacidosis at diagnosis of type 1 diabetes in children and adolescents. Diabetes Care. 2010; 33(7): 1500-2[DOI][PubMed]
  • 20. Teddy Study Group . The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Ann N Y Acad Sci. 2008; 1150: 1-13[DOI][PubMed]
  • 21. Sadauskaite Kuehne V, Samuelsson U, Jasinskiene E, Padaiga Z, Urbonaite B, Edenvall H, et al. Severity at onset of childhood type 1 diabetes in countries with high and low incidence of the condition. Diabetes Res Clin Pract. 2002; 55(3): 247-54
  • 22. Quinn M, Fleischman A, Rosner B, Nigrin DJ, Wolfsdorf JI. Characteristics at diagnosis of type 1 diabetes in children younger than 6 years. J Pediatr. 2006; 148(3): 366-71[DOI][PubMed]
  • 23. Bui H, To T, Stein R, Fung K, Daneman D. Is diabetic ketoacidosis at disease onset a result of missed diagnosis? J Pediatr. 2010; 156(3): 472-7[DOI][PubMed]
  • 24. Bober E, Dundar B, Buyukgebiz A. Partial remission phase and metabolic control in type 1 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab. 2001; 14(4): 435-41[PubMed]
  • 25. Xin Y, Yang M, Chen XJ, Tong YJ, Zhang LH. Clinical features at the onset of childhood type 1 diabetes mellitus in Shenyang, China. J Paediatr Child Health. 2010; 46(4): 171-5[DOI][PubMed]
  • 26. Yang Z, Zhou F, Dorman J, Wang H, Zu X, Mazumdar S, et al. Association between infectious diseases and type 1 diabetes: a case-crossover study. Pediatr Diabetes. 2006; 7(3): 146-52[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments