Journal of Pediatrics Review

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Extended-Interval Dosing of Aminoglycosides in Pediatrics: A Narrative Review

Ebrahim Salehifar 1 and Mohammad Reza Rafati 2 , *
Authors Information
1 Department of Clinical Pharmacy, Thalassemia Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IR Iran
2 Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IR Iran
Article information
  • Journal of Pediatrics Review: July 28, 2015, 3 (2); e2652
  • Published Online: July 20, 2015
  • Article Type: Review Article
  • Received: June 6, 2015
  • Revised: July 12, 2015
  • Accepted: July 14, 2015
  • DOI: 10.17795/jpr-2652

To Cite: Salehifar E, Rafati M R. Extended-Interval Dosing of Aminoglycosides in Pediatrics: A Narrative Review, J Pediatr Rev. 2015 ;3(2):e2652. doi: 10.17795/jpr-2652.

Copyright © 2015, Mazandaran University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Pagkalis S, Mantadakis E, Mavros MN, Ammari C, Falagas ME. Pharmacological considerations for the proper clinical use of aminoglycosides. Drugs. 2011; 71(17): 2277-94[DOI][PubMed]
  • 2. Jaeger BA, Jueckstock J, Andergassen U, Salmen J, Schochter F, Fink V, et al. Evaluation of two different analytical methods for circulating tumor cell detection in peripheral blood of patients with primary breast cancer. Biomed Res Int. 2014; 2014: 491459[DOI][PubMed]
  • 3. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR. Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death. Pediatrics. 2006; 117(1): 67-74[DOI][PubMed]
  • 4. Eslami G, Salehifar E, Behbudi M, Rezai MS. Rational Use of Amikacin in Buali-Sina Hospital in Sari 2011. J Mazandaran Univ Med Sci. 2013; 23(100): 2-9
  • 5. Cox CE. Gentamicin. Med Clin North Am. 1970; 54(5): 1305-15[PubMed]
  • 6. Salehifar E, Nasehi M, Eslami G, Sahraei S, Alizadeh Navaei R. Determination of antibiotics consumption in buali-sina pediatric hospital, sari 2010-2011. Iran J Pharm Res. 2014; 13(3): 995-1001[PubMed]
  • 7. Abedi S, Salehi Far E, Sharifpour A, Aliali M. Hospital-acquired pneumonia (HAP) in patients admitted in Imam Khomeini Hospital between January and August 2012. Eur Rep J. 2013; 42
  • 8. Khorasani G, Salehifar E, Eslami G. Profile of microorganisms and antimicrobial resistance at a tertiary care referral burn centre in Iran: emergence of Citrobacter freundii as a common microorganism. Burns. 2008; 34(7): 947-52[DOI][PubMed]
  • 9. Langhendries JP, Battisti O, Bertrand JM, Francois A, Kalenga M, Darimont J, et al. Adaptation in neonatology of the once-daily concept of aminoglycoside administration: evaluation of a dosing chart for amikacin in an intensive care unit. Biol Neonate. 1998; 74(5): 351-62[PubMed]
  • 10. Novelli A, Mazzei T, Fallani S, Cassetta MI, Conti S. In vitro postantibiotic effect and postantibiotic leukocyte enhancement of tobramycin. J Chemother. 1995; 7(4): 355-62[DOI][PubMed]
  • 11. Kiatchoosakun P, Kosalaraksa P, Jirapradittha J, Taksaphan S, Tassniyom S. Once-daily gentamicin dosing of 4 mg/kg/dose in neonates. J Med Assoc Thai. 2005; 88(7): 934-8
  • 12. Boyer A, Gruson D, Bouchet S, Clouzeau B, Hoang-Nam B, Vargas F, et al. Aminoglycosides in septic shock: an overview, with specific consideration given to their nephrotoxic risk. Drug Saf. 2013; 36(4): 217-30[DOI][PubMed]
  • 13. Agarwal G, Rastogi A, Pyati S, Wilks A, Pildes RS. Comparison of once-daily versus twice-daily gentamicin dosing regimens in infants > or = 2500 g. J Perinatol. 2002; 22(4): 268-74[DOI][PubMed]
  • 14. Li J, Nekka F. A rational quantitative approach to determine the best dosing regimen for a target therapeutic effect: a unified formalism for antibiotic evaluation. J Theor Biol. 2013; 319: 88-95[DOI][PubMed]
  • 15. Ahmed A, Paris MM, Trujillo M, Hickey SM, Wubbel L, Shelton SL, et al. Once-daily gentamicin therapy for experimental Escherichia coli meningitis. Antimicrob Agents Chemother. 1997; 41(1): 49-53[PubMed]
  • 16. Kosalaraksa P, Janthep P, Jirapradittha J, Taksaphan S, Kiatchoosakun P. Once versus twice daily dose of gentamicin therapy in Thai neonates. J Med Assoc Thai. 2004; 87(4): 372-6
  • 17. Low YS, Tan SL, Wan AS. Extended-interval gentamicin dosing in achieving therapeutic concentrations in malaysian neonates. J Pediatr Pharmacol Ther. 2015; 20(2): 119-27[DOI][PubMed]
  • 18. Alshaikh B, Dersch-Mills D, Taylor R, Akierman AR, Yusuf K. Extended interval dosing of gentamicin in premature neonates </= 28-week gestation. Acta Paediatr. 2012; 101(11): 1134-9[DOI][PubMed]
  • 19. Berger A, Kretzer V, Gludovatz P, Heinze G, Haiden N, Pollak A. Evaluation of an amikacin loading dose for nosocomial infections in very low birthweight infants. Acta Paediatr. 2004; 93(3): 356-60[PubMed]
  • 20. Lundergan FS, Glasscock GF, Kim EH, Cohen RS. Once-daily gentamicin dosing in newborn infants. Pediatrics. 1999; 103(6): 1228-34[PubMed]
  • 21. Frymoyer A, Lee S, Bonifacio SL, Meng L, Lucas SS, Guglielmo BJ, et al. Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia. J Perinatol. 2013; 33(10): 778-82[DOI][PubMed]
  • 22. Mercado MC, Brodsky NL, McGuire MK, Hurt H. Extended interval dosing of gentamicin in preterm infants. Am J Perinatol. 2004; 21(2): 73-7[DOI][PubMed]
  • 23. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM. Once- versus twice-daily gentamicin dosing in neonates >/=34 Weeks' gestation: cost-effectiveness analyses. Pediatrics. 1999; 103(3): 594-8[PubMed]
  • 24. Alsaedi SA. Once daily gentamicin dosing in full term neonates. Saudi Med J. 2003; 24(9): 978-81[PubMed]
  • 25. Tiwari S, Rehan HS, Chandra J, Mathur NN, Singh V. Efficacy and safety of a single daily dose of gentamicin in hospitalized Indian children: a quasi-randomized trial. J Antimicrob Chemother. 2009; 64(5): 1096-101[DOI][PubMed]
  • 26. Sung L, Dupuis LL, Bliss B, Taddio A, Abdolell M, Allen U, et al. Randomized controlled trial of once- versus thrice-daily tobramycin in febrile neutropenic children undergoing stem cell transplantation. J Natl Cancer Inst. 2003; 95(24): 1869-77[PubMed]
  • 27. de Hoog M, Mouton JW, van den Anker JN. New dosing strategies for antibacterial agents in the neonate. Semin Fetal Neonatal Med. 2005; 10(2): 185-94[DOI][PubMed]
  • 28. Iwai N, Sasaki A, Taneda Y, Mizoguchi F, Nakamura H, Kawamura M, et al. [Pharmacokinetics in neonates and infants following administration of amikacin]. Jpn J Antibiot. 1987; 40(6): 1157-75[PubMed]
  • 29. Egan S, Murphy PG, Fennell JP, Kelly S, Hickey M, McLean C, et al. Using Six Sigma to improve once daily gentamicin dosing and therapeutic drug monitoring performance. BMJ Qual Saf. 2012; 21(12): 1042-51[DOI][PubMed]
  • 30. Jang SB, Lee YJ, Park MS, Song YG, Kim JH, Kim HK, et al. Population pharmacokinetics of amikacin in a Korean clinical population. Int J Clin Pharmacol Ther. 2011; 49(6): 371-81[PubMed]
  • 31. Best EJ, Gazarian M, Cohn R, Wilkinson M, Palasanthiran P. Once-daily gentamicin in infants and children: a prospective cohort study evaluating safety and the role of therapeutic drug monitoring in minimizing toxicity. Pediatr Infect Dis J. 2011; 30(10): 827-32[DOI][PubMed]
  • 32. de Hoog M, Mouton JW, Schoemaker RC, Verduin CM, van den Anker JN. Extended-interval dosing of tobramycin in neonates: implications for therapeutic drug monitoring. Clin Pharmacol Ther. 2002; 71(5): 349-58[DOI][PubMed]
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