Intravenous Immunoglobulin Resistant Kawasaki Disease

Mohammad Reza Navaeifar; Mohammad Sadegh Rezaei

Intravenous Immunoglobulin Resistant Kawasaki Disease

Mohammad Reza Navaeifar ¹ and Mohammad Sadegh Rezaei ^{2
, *}

Authors Information

¹ Nosocomial Infection Research Centre, Mazandaran University of Medical Sciences, Sari, Iran

² Department of Pediatric Infectious Disease,Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Article information

Journal of Pediatrics Review: January 31, 2013, 1 (1); 44-52
Published Online: January 31, 2013
Article Type: Review Article
Received: April 23, 2012
Accepted: April 23, 2012

To Cite: Navaeifar M R, Rezaei M S. Intravenous Immunoglobulin Resistant Kawasaki Disease, J Pediatr Rev. 2013 ;1(1):44-52.

Abstract

Kawasaki disease is a systemic vasculitis that mainly affects younger children. Although the definite cause still remains unknown but the clinical and epidemiologic findings discuss an infectious cause. The prevalence of incomplete Kawasaki disease reported 15 to 36.2%, and it is more frequent in the extremes of the age spectrum. Non delayed treatment of disease should be initiated because of critical cardiac vascular complications. Up to 15% - 25% of patients with Kawasaki disease who remain febrile after administration of first dose of intravenous immunoglobin plus aspirin are classified as refractory disease. These intravenous immunoglobin resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potentially non responder and treatment of intravenous immunoglobin resistant patients is now controversial but some useful points were recommended.

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