A Systematic Review of Single Nucleotide Polymorphisms Associated With Metabolic Syndrome in Children and Adolescents

Authors Information
Article Notes and Dates
To Cite : Kelishadi R, Hovsepian S, Haghjooy Javanmard S. A Systematic Review of Single Nucleotide Polymorphisms Associated With Metabolic Syndrome in Children and Adolescents, J Pediatr Rev. 2018 ;6(1):e10536. doi: 10.5812/jpr.10536.
Copyright: Copyright © 2018, Journal of Pediatrics Review. .
Abstract
1. Context
2. Objectives
3. Data Sources
4. Study Selection and Data Extraction
5. Results
6. Discussion
7. Conclusions
Footnote
References
  • 1. Alberti KG, Zimmet P, Shaw J, I. D. F. Epidemiology Task Force Consensus Group . The metabolic syndrome--a new worldwide definition. Lancet. 2005;366(9491):1059-62. doi: 10.1016/S0140-6736(05)67402-8. [PubMed: 16182882].
  • 2. Weiss R. Childhood metabolic syndrome: must we define it to deal with it?. Diabetes Care. 2011;34 Suppl 2:S171-6. doi: 10.2337/dc11-s214. [PubMed: 21525451].
  • 3. Ford ES. The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study. Atherosclerosis. 2004;173(2):309-14. doi: 10.1016/j.atherosclerosis.2003.12.022. [PubMed: 15064107].
  • 4. Agirbasli M, Tanrikulu AM, Berenson GS. Metabolic Syndrome: Bridging the Gap from Childhood to Adulthood. Cardiovasc Ther. 2016;34(1):30-6. doi: 10.1111/1755-5922.12165. [PubMed: 26588351].
  • 5. Aguilera CM, Olza J, Gil A. Genetic susceptibility to obesity and metabolic syndrome in childhood. Nutr Hosp. 2013;28 Suppl 5:44-55. doi: 10.3305/nh.2013.28.sup5.6917. [PubMed: 24010743].
  • 6. Taylor JY, Kraja AT, de Las Fuentes L, Stanfill AG, Clark A, Cashion A. An overview of the genomics of metabolic syndrome. J Nurs Scholarsh. 2013;45(1):52-9. doi: 10.1111/j.1547-5069.2012.01484.x. [PubMed: 23368731].
  • 7. Bellia A, Giardina E, Lauro D, Tesauro M, Di Fede G, Cusumano G, et al. "The Linosa Study": epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate. Nutr Metab Cardiovasc Dis. 2009;19(7):455-61. doi: 10.1016/j.numecd.2008.11.002. [PubMed: 19201175].
  • 8. Wang XM. Early life programming and metabolic syndrome. World J Pediatr. 2013;9(1):5-8. doi: 10.1007/s12519-013-0403-7. [PubMed: 23389329].
  • 9. Chang HW, Lin FH, Li PF, Huang CL, Chu NF, Su SC, et al. Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents. Genet Test Mol Biomarkers. 2016;20(3):137-42. doi: 10.1089/gtmb.2015.0241. [PubMed: 26799416].
  • 10. Kim K, Ahn N, Park J, Koh J, Jung S, Kim S, et al. Association of angiotensin-converting enzyme I/D and alpha-actinin-3 R577X genotypes with metabolic syndrome risk factors in Korean children. Obes Res Clin Pract. 2016;10 Suppl 1:S125-32. doi: 10.1016/j.orcp.2015.09.008. [PubMed: 26483160].
  • 11. Nikpour P, Emadi-Baygi M, Fatemi SG, Kelishadi R. Absence of association between -286C>A>T polymorphism in the CRP gene and metabolic syndrome in Iranian pediatric. Adv Biomed Res. 2015;4:210. doi: 10.4103/2277-9175.166147. [PubMed: 26605239].
  • 12. Marcil V, Amre D, Seidman EG, Boudreau F, Gendron FP, Menard D, et al. Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth. PLoS One. 2015;10(2). e0117238. doi: 10.1371/journal.pone.0117238. [PubMed: 25671620].
  • 13. White MJ, Eren F, Agirbasli D, Williams SM, Agirbasli M. SHBG gene polymorphism (rs1799941) associates with metabolic syndrome in children and adolescents. PLoS One. 2015;10(2). e0116915. doi: 10.1371/journal.pone.0116915. [PubMed: 25647406].
  • 14. Alegria-Torres JA, Garcia-Dominguez ML, Cruz M, Aradillas-Garcia C. Q192R polymorphism of paraoxonase 1 gene associated with insulin resistance in Mexican children. Arch Med Res. 2015;46(1):78-83. doi: 10.1016/j.arcmed.2014.12.001. [PubMed: 25500007].
  • 15. Li P, Jiang R, Li L, Liu C, Yang F, Qiu Y. Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents. Eur J Clin Nutr. 2015;69(1):62-7. doi: 10.1038/ejcn.2014.152. [PubMed: 25074391].
  • 16. Gamboa-Melendez MA, Galindo-Gomez C, Juarez-Martinez L, Gomez FE, Diaz-Diaz E, Avila-Arcos MA, et al. Novel association of the R230C variant of the ABCA1 gene with high triglyceride levels and low high-density lipoprotein cholesterol levels in Mexican school-age children with high prevalence of obesity. Arch Med Res. 2015;46(6):495-501. doi: 10.1016/j.arcmed.2015.07.008. [PubMed: 26256050].
  • 17. Nikpour P, Miranzadeh-Mahabadi H, Emadi-Baygi M, Kelishadi R. Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance. J Pediatr Endocrinol Metab. 2014;27(7-8):611-5. doi: 10.1515/jpem-2014-0115. [PubMed: 24825092].
  • 18. Fatemi SG, Emadi-Baygi M, Nikpour P, Kelishadi R, Hashemipour M. Absence of Association between -1131T>C Polymorphism in the Apolipoprotein APOA5 Gene and Pediatric Metabolic Syndrome. Iran J Pediatr. 2014;24(3):319-22. [PubMed: 25562027].
  • 19. Zhao X, Xi B, Shen Y, Wu L, Hou D, Cheng H, et al. An obesity genetic risk score is associated with metabolic syndrome in Chinese children. Gene. 2014;535(2):299-302. doi: 10.1016/j.gene.2013.11.006. [PubMed: 24269186].
  • 20. De la Cruz-Mosso U, Munoz-Valle JF, Salgado-Goytia L, García-Carreón A, Illades-Aguiar B, Castaneda-Saucedo E, et al. Relationship of metabolic syndrome and its components with -844 G/A and HindIII C/G PAI-1 gene polymorphisms in Mexican children. BMC Pediatr. 2012;12(1). doi: 10.1186/1471-2431-12-41.
  • 21. Juarez-Meavepena M, Carreon-Torres E, Lopez-Osorio C, Garcia-Sanchez C, Gamboa R, Torres-Tamayo M, et al. The Srb1+1050T allele is associated with metabolic syndrome in children but not with cholesteryl ester plasma concentrations of high-density lipoprotein subclasses. Metab Syndr Relat Disord. 2012;10(2):110-6. doi: 10.1089/met.2011.0071. [PubMed: 22182283].
  • 22. Hsieh CH, Hung YJ, Wu LI, He CT, Lee CH, Hsiao FC, et al. Interleukin-6 receptor gene 48892 A/C polymorphism is associated with metabolic syndrome in female Taiwanese adolescents. Genet Test Mol Biomarkers. 2012;16(12):1376-81. doi: 10.1089/gtmb.2012.0188. [PubMed: 23094986].
  • 23. Smart MC, Dedoussis G, Yiannakouris N, Grisoni ML, Dror GK, Yannakoulia M, et al. Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures. Nutr Metab Cardiovasc Dis. 2011;21(7):476-84. doi: 10.1016/j.numecd.2009.12.004. [PubMed: 20227263].
  • 24. Alavi-Shahri J, Behravan J, Hassany M, Tatari F, Kasaian J, Ganjali R, et al. Association between angiotensin II type 1 receptor gene polymorphism and metabolic syndrome in a young female Iranian population. Arch Med Res. 2010;41(5):343-9. doi: 10.1016/j.arcmed.2010.06.007. [PubMed: 20851291].
  • 25. Liu PH, Chang YC, Jiang YD, Chen WJ, Chang TJ, Kuo SS, et al. Genetic variants of TCF7L2 are associated with insulin resistance and related metabolic phenotypes in Taiwanese adolescents and Caucasian young adults. J Clin Endocrinol Metab. 2009;94(9):3575-82. doi: 10.1210/jc.2009-0609. [PubMed: 19509102].
  • 26. Gianotti TF, Sookoian S, Dieuzeide G, Garcia SI, Gemma C, Gonzalez CD, et al. A decreased mitochondrial DNA content is related to insulin resistance in adolescents. Obesity (Silver Spring). 2008;16(7):1591-5. doi: 10.1038/oby.2008.253. [PubMed: 18451773].
  • 27. Park HS, Shin ES, Lee JE. Genotypes and haplotypes of beta2-adrenergic receptor and parameters of the metabolic syndrome in Korean adolescents. Metabolism. 2008;57(8):1064-70. doi: 10.1016/j.metabol.2008.03.009. [PubMed: 18640383].
  • 28. Sookoian S, Garcia SI, Gianotti TF, Dieuzeide G, Gonzalez CD, Pirola CJ. The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome. Am J Hypertens. 2005;18(10):1271-5. doi: 10.1016/j.amjhyper.2005.04.014. [PubMed: 16202847].
  • 29. Mangge H, Baumgartner BG, Zelzer S, Pruller F, Schnedl WJ, Reininghaus EZ, et al. Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages. Aliment Pharmacol Ther. 2015;42(1):99-105. doi: 10.1111/apt.13232. [PubMed: 25939720].
  • 30. Suazo J, Smalley SV, Hodgson MI, Weisstaub G, Gonzalez A, Santos JL. [Association between genetic polymorphisms of interleukin 6 (IL6), IL6R and IL18 with metabolic syndrome in obese Chilean children]. Rev Med Chil. 2014;142(3):290-8. doi: 10.4067/S0034-98872014000300002. [PubMed: 25052265].
  • 31. Zaki M, Amr K. Apolipoprotein A5 T-1131C variant and risk for metabolic syndrome in obese adolescents. Gene. 2014;534(1):44-7. doi: 10.1016/j.gene.2013.10.032. [PubMed: 24161374].
  • 32. Suazo J, Hodgson MI, Obregon AM, Valladares M, Weisstaub G, Amador P, et al. Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system. J Pediatr Endocrinol Metab. 2013;26(11-12):1131-9. doi: 10.1515/jpem-2013-0084. [PubMed: 23817596].
  • 33. Olza J, Gil-Campos M, Leis R, Ruperez AI, Tojo R, Canete R, et al. Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children. Peptides. 2013;45:22-7. doi: 10.1016/j.peptides.2013.04.007. [PubMed: 23624317].
  • 34. Oguri K, Tachi T, Matsuoka T. Visceral fat accumulation and metabolic syndrome in children: the impact of Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Acta Paediatr. 2013;102(6):613-9. doi: 10.1111/apa.12149. [PubMed: 23282015].
  • 35. Miranda JA, Belo VA, Souza-Costa DC, Lanna CM, Tanus-Santos JE. eNOS polymorphism associated with metabolic syndrome in children and adolescents. Mol Cell Biochem. 2013;372(1-2):155-60. doi: 10.1007/s11010-012-1456-y. [PubMed: 22983816].
  • 36. Komsu-Ornek Z, Demirel F, Dursun A, Ermis B, Piskin E, Bideci A. Leptin receptor gene Gln223Arg polymorphism is not associated with obesity and metabolic syndrome in Turkish children. Turk J Pediatr. 2012;54(1):20-4. [PubMed: 22397037].
  • 37. Dusatkova L, Zamrazilova H, Sedlackova B, Vcelak J, Hlavaty P, Aldhoon Hainerova I, et al. Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 Czech adolescents. Folia Biol (Praha). 2013;59(3):123-33. [PubMed: 23890480].
  • 38. Gao L, Zheng Z, Cao L, Shen S, Yang Y, Zhao Z, et al. The growth hormone receptor (GHR) exon 3 polymorphism and its correlation with metabolic profiles in obese Chinese children. Pediatr Diabetes. 2011;12(4 Pt 2):429-34. doi: 10.1111/j.1399-5448.2010.00747.x. [PubMed: 21470351].
  • 39. Pyrzak B, Wisniewska A, Popko K, Demkow U, Kucharska AM. Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children. Eur J Med Res. 2010;15 Suppl 2:141-6. [PubMed: 21147642].
  • 40. Shcherbakova M, Sinitsin PA, Poriadina GI, Larionova VI, Khmyrova AP, Petriaĭkina EE, et al. Correlation of metabolic syndrome clinical signs and genetic determinants at children with obese. Eksperimental'naia i klinicheskaia gastroenterologiia. 2009;(7):6-11.
  • 41. Khalyfa A, Bhushan B, Hegazi M, Kim J, Kheirandish-Gozal L, Bhattacharjee R, et al. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. Lipids Health Dis. 2010;9:18. doi: 10.1186/1476-511X-9-18. [PubMed: 20156355].
  • 42. Santoro N, Cirillo G, Lepore MG, Palma A, Amato A, Savarese P, et al. Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity. J Clin Endocrinol Metab. 2009;94(1):300-5. doi: 10.1210/jc.2008-1659. [PubMed: 18940878].
  • 43. Pyrzak B, Wisniewska A, Majcher A, Popko K, Wasik M, Demkow U. Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children. Eur J Med Res. 2009;14 Suppl 4:196-200. [PubMed: 20156756].
  • 44. Deram S, Nicolau CY, Perez-Martinez P, Guazzelli I, Halpern A, Wajchenberg BL, et al. Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. J Clin Endocrinol Metab. 2008;93(12):4933-40. doi: 10.1210/jc.2008-0947. [PubMed: 18812483].
  • 45. Pyrzak B, Wiśniewska A, Rymkiewicz-Kluczynska B. Tumor necrosis factor alpha (TNF-alpha) gene G-308A polymorphism relationship to insulin resistance and lipid abnormalities in children with obesity. Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego: organ Polskiego Towarzystwa Endokrynologow Dzieciecych. 2005;12(3):171-4.
  • 46. Santoro N, Cirillo G, Amato A, Luongo C, Raimondo P, D'Aniello A, et al. Insulin gene variable number of tandem repeats (INS VNTR) genotype and metabolic syndrome in childhood obesity. J Clin Endocrinol Metab. 2006;91(11):4641-4. doi: 10.1210/jc.2005-2705. [PubMed: 16868061].
  • 47. Palomaki GE, Melillo S, Bradley LA. Association between 9p21 genomic markers and heart disease: a meta-analysis. JAMA. 2010;303(7):648-56. doi: 10.1001/jama.2010.118. [PubMed: 20159873].
  • 48. Povel CM, Boer JM, Reiling E, Feskens EJ. Genetic variants and the metabolic syndrome: a systematic review. Obes Rev. 2011;12(11):952-67. doi: 10.1111/j.1467-789X.2011.00907.x. [PubMed: 21749608].
  • 49. Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS, et al. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet. 2012;5(2):242-9. doi: 10.1161/CIRCGENETICS.111.961482. [PubMed: 22399527].
  • 50. Stancakova A, Laakso M. Genetics of metabolic syndrome. Rev Endocr Metab Disord. 2014;15(4):243-52. doi: 10.1007/s11154-014-9293-9. [PubMed: 25124343].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiaion Alert via Google Reader

Cited By: