Introduction: One of the most common nutritional deficiencies worldwide is iron deficiency. Fatigue, pallor, vertigo, dyspnea, cold intolerance, lethargy, palpitation, headache and pallor of the mucous membranes or nail beds are the most common symptoms and signs of iron deficiency. Thrombocytosis is commonly seen in iron deficiency anemia, and it seems that erythropoietin plays the main role in this finding. At the other hand, thrombocytopenia and even leukopenia have been reported in iron deficiency, but pancytopenia is a very rare condition.
Case Presentation: In this report, we present two unusual cases of pancytopenia due to severe iron deficiency that improved after treatment with oral iron supplements.
Conclusion: Iron deficiency anemia, if sufficiently severe, may be associated with reduced platelet and leukocyte counts and should be considered as a differential diagnosis in all patients with pancytopenia.