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1- Allergy Research Center, Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2- Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , zkanannejad@gmail.com
Abstract:   (151 Views)
Context: Chronic airway inflammation in asthma is affected by a complex network of interacting cytokines. The exact role of each cytokine in childhood asthma development remains poorly understood. In this study, we aimed to review articles investigating cytokine levels and polymorphisms in childhood asthma among the Iranian populations to assess susceptible cytokines related to childhood asthma.
Evidence acquisition: We performed a literature search by using PubMed, Scopus, Science direct, and Embase databases to find articles that have evaluated the cytokine levels and gene polymorphisms in childhood asthma in the Iranian population until March 2, 2020. The terms used to search were including cytokine, interleukin, polymorphism, asthma, and Iran for international databases. Only, case-control studies with a healthy control group that investigated cytokine level and polymorphism in childhood asthma among the Iranian population have been included.
Results: Considering these criteria, 7 articles were extracted from international databases and included in the current review. We investigated 4 cytokine levels and 4 cytokine polymorphisms patterns in asthmatic and non-asthmatic subjects in Iran. IL-23, IL-17, and IL-33 levels were statistically higher in asthmatic children and also IL-33, IL-17 levels were associated with asthma severity. There were no significant differences between healthy and asthmatic subjects regarding IL-35 levels. Polymorphisms in cytokine IL-4, IL-10, TNF-α, and IL-2 were susceptible to childhood asthma in the Iranian population.
Conclusion: Increased IL-33 and IL-17 levels were related to disease severity in childhood asthma. Four cytokine polymorphisms (IL-4, IL-10, IL-2, and TNF-α) were associated with the risk of pediatric asthma in the Iranian population.
Full-Text [PDF 648 kb]   (43 Downloads)    
Type of Study: Narrative Review | Subject: Allergy and Clinical Immunology
Received: 2020/04/27 | Accepted: 2020/06/13 | Published: 2019/07/19

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