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1- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran , javadneg@yahoo.com
3- Department of Immunology, Asthma, Allergy & Immunology Research Center, Birjand University of Medical Sciences, Birjand, Iran
4- Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, afrouz.alipour@gmail.com
Abstract:   (459 Views)
Background: Exposure to house dust mites is an important cause of asthma development among children. The most important asthma-causing mites found in homes are Dermatophagoides farinae (Der f1), and D. pteronyssinus (Der p1). Der f1 or Der p1 are as allergens of mites The aim of this study was to assess the levels of Der p1, and Der f1 in homes of families that had a case of childhood asthma in a northern city of Iran and to determine the association between indoor house environment and the level of mites present there.
Method: Dust samples were collected from bedrooms of 91 homes of families that had case of childhood asthma. Families filled a questionnaire about demographical characteristics and the indoor condition of their living environment. The levels of Der f1 and Der p1 were measured by enzyme linked immunosorbent assay (ELISA). Statistical analysis was performed by SPSS 24 and P value < 0.05 considered significant.
Results: we found that Der p1 was more prevalent among samples than Der f1. Mean concentration of Der p1 concentration was 271.35 ng/g( 9 times greater than the concentration of Der f1). When the indoor environment status was evaluated, it was found that keeping pets and having old carpets are associated with Der f1 (P<0.05). However, no significant association was found between Der p1 and the indoor conditions of the home.
Conclusions: Our study showed that Der p1 is more common than Der f1 in house of children with asthma. We suggest removing carpets and pets from house.
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Type of Study: Original Article | Subject: Allergy and Clinical Immunology
Received: 2020/01/11 | Accepted: 2020/04/19 | Published: 2019/07/19

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