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1- Department of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
2- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Pediatric, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , azarfara@mums.ac.ir
6- Department of Pediatric, Mashhad Branch, Islamic Azad University, Mashhad, Iran
7- Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (216 Views)

Objectives: Different types of researches have been done so far on drug safety and efficacy in children with refractory nephrotic syndrome. Ofatumumab might be an effective drug for this syndrome; however, the long-term effects and cost-effectiveness of ofatumumab treatment have not been comprehensively assessed. This study aims to perform a systematic review of the efficacy and safety of ofatumumab in children with difficult-to-treat nephrotic syndrome.
Study Selection: An electronic literature search was conducted to identify appropriate studies. The search term was: (“nephrotic syndrome” or “minimal change disease” or “focal segmental glomerulosclerosis” or membranous) and (‘‘ofatumumab’’ or‘‘CD20’’ or "Arzerra" or "HuMax-CD20").
Data Extraction: Data were extracted from the articles according to the selection criteria by two independent reviewers.
Results: A total of 83 potentially relevant articles were identified. Thirty-two articles were removed due to duplication. Besides, 26 more articles were excluded because they were book sections and review papers and therefore not relevant. Another 14 items were removed after reviewing the full text of selected papers because the topics did not fit our subject. Finally, 11 studies were selected in our systematic review. The metric considered to assess the efficacy of Ofatumumab in children with nephrotic syndrome in most of the studies was a complete remission rate.
Conclusions: In conclusion, our systematic review showed that Ofatumumab may be an effective drug in refractory nephrotic syndrome treatment in children and could bring down the use of steroids and immunosuppressants. However, further large randomized trials are suggested.

Full-Text [PDF 704 kb]   (33 Downloads)    
Type of Study: Systematic Review | Subject: Pediatric Nephrology
Received: 2019/10/19 | Accepted: 2020/06/4 | Published: 2019/07/19

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