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1- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2- Molecular and Cell Biology Research Center, Department of Immunology,Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3- Antimicrobial Resistance Research Center, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
4- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran , drmsrezaii49@gmail.com
Abstract:   (101 Views)
Background: The Methicillin-Resistant Staphylococcus aureus (MRSA) strains, are cause of wide spectrum infections in hospitals and responsible of majority of community-acquired infections. The emergence of community-acquired MRSA in patients without risk factors represents a high risk for public health.
Objectives: In this study we aimed to molecular typing of nasal carriage MRSA strains harbored mec A gene isolated from healthy children in North of Iran and also to determine the pattern of vancomycin susceptibility in these isolates.  
Methods: The MRSA strains were identified using standard microbiological and molecular procedures from the nose of apparently healthy children .Antibiotic susceptibility test was performed according to the Clinical and Laboratory Standards Institute (CLSI). The MRSA strains were characterized by spa typing.
Results: In total, 14 different patterns of spa gene were obtained in MRSA isolates in this study, which included t790 (23.07%), t2962 (15.38%), t267 (15.38%), t159 (7.69%) and t701, t094, t1816, t11332, t937, t2135, t180, t160 (1 isolates (3.84%) per each types). The rate of resistant isolates to cefoxitin, , cefalotin, clindamycin, ,cefazolin, co-amoxiclav, , cotrimoxazole and cephalexin antibiotics were  69.23%, 100%, 46.15%, 96.15%, 100, 3.48% and 100% respectively. Totally 6 (23.07%) and 5 (19.23%) isolates revealed VISA and VRSA phenotype respectively.
Conclusions: This study showed the different variant of MRSA strains based on molecular typing, among healthy children. Continuous surveillance study to monitoring MRSA should be encouraged to gain a better understanding of the circulating MRSA strains in order to prevent community spread of this pathogen.
 
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Type of Study: Original Article | Subject: Pediatric infection disease
Received: 2019/08/4 | Accepted: 2019/08/11

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